Skel.js is a tiny JavaScript framework (~6kb gzipped and minified) that simplifies building responsive layouts very much. It has a JavaScript-powered and 12-column grid system that can handle any type of complex layouts + has easy-to-understand rules.
Managing breakpoints is just about adding the width ranges in the options of the skel.js‘ main function.
There is a plugin system for extending it further (a UI plugin is mentioned to be released soon).
Also, many helpful options exist like the ability to applying reset.css or normalize.css and defining the box model instantly.
Requirements: No Requirements
Compatibility: All Major Browsers
Compatibility: All Major Browsers
Website: http://skeljs.org/