Cardinal is a small and mobile-first CSS framework that positions itself as a starter-kit, provides the basics and lets the users customize/develop the rest.
Hitch is a lightweight JavaScript library that adds expressive capabilities to CSS files. It has some of the powers of CSS preprocessors like prefixing or variables but also some other stuff.
Skel.js is a tiny JavaScript framework what have a 12-column grid system (~6kb gzipped and minified) that simplifies building responsive layouts very much.